4 Preprocessing (slides)
4.1 Extracellular recordings with Neuropixels
Olivier Winter (~20 mins)
This presentation introduces the fundamentals of extracellular neurophysiology, specifically focusing on recordings using Neuropixel probes. It outlines key concepts like hardware, sampling theory, and the physiological basis of Local-Field Potentials (LFP) and Action Potentials (AP).
4.2 Sampling the extracellular voltage
Olivier Winter (~20 mins)
This presentation focuses on sampling theory and hardware components such as analog-to-digital converters, Nyquist frequency, and grounding techniques. Additionally, it compares the technical specifications and structural configurations of Neuropixels 1 and 2 probes.
4.3 Preprocessing of the AP band
Olivier Winter and Joe Ziminski (~40 mins)
- Data preparation
- Compression
- Shank splitting for NP2
- Saturation detection
- Pre-processing
- ADC rephasing
- Bad channels detection
- CAR / Spatial filter
- Saturation Application
- Whitening